Human TIMP-1 (Metalloproteinase Inhibitor 1) Antibody Pair (STJAP00061)
General Information
| Short Description | This TIMP-1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Polyclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | TIMP1 |
| Gene ID | 7076 |
| Uniprot ID | TIMP1_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human TIMP-1 protein.Detection Immunogen: Recombinant Human TIMP-1 protein. |
Additional Info
| Post Translational Modifications | The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated. |
| Function | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro.but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. |
| Protein Name | Metalloproteinase Inhibitor 1Erythroid-Potentiating ActivityEpaFibroblast Collagenase InhibitorCollagenase InhibitorTissue Inhibitor Of Metalloproteinases 1Timp-1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1592389Reactome: R-HSA-381426Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-8957275Reactome: R-HSA-9839383 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Metalloproteinase Inhibitor 1 antibody pairErythroid-Potentiating Activity antibody pairEpa antibody pairFibroblast Collagenase Inhibitor antibody pairCollagenase Inhibitor antibody pairTissue Inhibitor Of Metalloproteinases 1 antibody pairTimp-1 antibody pairTIMP1 antibody pairCLGI antibody pairTIMP antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human TIMP-1 (Metalloproteinase Inhibitor 1) Antibody Pair (STJAP00061)
This antibody pair detects human TIMP-1 (Metalloproteinase Inhibitor 1), corresponding to UniProt accession P01033. Reactivity is confirmed for human samples only.
The capture antibody is an unconjugated mouse monoclonal antibody supplied at 0.5 mg/mL in PBS with 0.04% Proclin 300 and 50% glycerol, pH 7.4. The detection antibody is a biotin-conjugated goat polyclonal antibody supplied at the same concentration and formulation.
This antibody pair is validated for use in ELISA. No other assay formats are specified for this product.
Both the capture and detection antibodies were raised against recombinant human TIMP-1 protein. The capture antibody was purified by Protein A or G, while the detection antibody was purified by antigen affinity.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.