Human TIMM8A protein (Recombinant) (N-His-SUMO) (STJP007950)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TIMM8A-N-His-SUMO protein was developed from e.coli for the region N-His-SUMO. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TIMM8A |
| Gene ID | 1678 |
| Uniprot ID | TIM8A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp16-Asp97 |
Additional Info
| Function | Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. |
| Protein Name | Mitochondrial Import Inner Membrane Translocase Subunit Tim8 ADeafness Dystonia Protein 1X-Linked Deafness Dystonia Protein |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinIntermembrane Side |
| Alternative Protein Names | Mitochondrial Import Inner Membrane Translocase Subunit Tim8 A proteinDeafness Dystonia Protein 1 proteinX-Linked Deafness Dystonia Protein proteinTIMM8A proteinDDP proteinDDP1 proteinTIM8A protein |
Information sourced from Uniprot.org