Human Thrombospondin 5/COMP protein (Recombinant) (His-Tag) (STJP019477)
SPECIFICATIONS
HostHEK293 Cells
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Thrombospondin 5/COMP-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | HEK293 Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid In Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
Target Information
| Gene Symbol | COMP |
| Gene ID | 1311 |
| Uniprot ID | COMP_HUMAN |
| Accession Number | NP_000086.2 |
| Immunogen | Human |
| Immunogen Region | 21-757aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. |
| Post Translational Modifications | Proteolytically cleaved by metalloproteases ADAMTS4 and ADAMTS1 with ADAMTS4 showing more potent activity. |
| Function | Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7. |
| Protein Name | Cartilage Oligomeric Matrix ProteinCompThrombospondin-5Tsp5 |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000178 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Cartilage Oligomeric Matrix Protein proteinComp proteinThrombospondin-5 proteinTsp5 proteinCOMP protein |
Information sourced from Uniprot.org