Human Thrombomodulin (Thrombomodulin) Antibody Pair (STJAP00707)
General Information
| Short Description | This Thrombomodulin antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R01-4F4/R08-5H0 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | THBD |
| Gene ID | 7056 |
| Uniprot ID | TRBM_HUMAN |
| Immunogen | Recombinant protein of human Thrombomodulin |
Additional Info
| Tissue Specificity | Endothelial cells are unique in synthesizing thrombomodulin. |
| Post Translational Modifications | N-glycosylated. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. |
| Function | Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response. |
| Protein Name | ThrombomodulinTmFetomodulinCd Antigen Cd141 |
| Database Links | Reactome: R-HSA-140875Reactome: R-HSA-202733 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Pair Names | Thrombomodulin antibody pairTm antibody pairFetomodulin antibody pairCd Antigen Cd141 antibody pairTHBD antibody pairTHRM antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human Thrombomodulin (Thrombomodulin) Antibody Pair (STJAP00707)
This antibody pair detects human Thrombomodulin (UniProt P07204) and has confirmed reactivity against human samples only. No cross-reactivity data for other species is provided.
This antibody pair has been validated for use in ELISA. No other assay formats are listed for this product.
Both antibodies are rabbit monoclonal IgGs supplied unconjugated at 1 mg/mL, formulated in 0.01M PBS at pH 7.2, and purified by affinity chromatography. The clone IDs are R01-4F4 and R08-5H0 respectively.
Both antibodies were raised against a recombinant protein of human Thrombomodulin. No specific immunogen region is defined in the product documentation.
The antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and keep at -20°C, and avoid repeated freeze/thaw cycles.
Working dilutions are determined by the end user and are not specified in the product data. Recommended sample types are also not defined, so researchers should optimize conditions empirically for their application.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.