Human THG1L protein (Recombinant) (His-Tag) (STJP017777)

Name: Human THG1L protein (Recombinant) (His-Tag) (STJP017777)
SKU: STJP017777
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017777

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Short Description	Recombinant-Human THG1L-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% Glycerol, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	THG1L
Gene ID	54974
Uniprot ID	THG1_HUMAN
Accession Number	NP_060342
Immunogen	Human
Immunogen Region	30-298aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MGSMAKSKFE YVRDFEADDT CLAHCWVVVR LDGRNFHRFA EKHNFAKPND SRALQLMTKC AQTVMEELED IVIAYGQSDE YSFVFKRKTN WFKRRASKFM THVASQFASS YVFYWRDYFE DQPLLYPPGF DGRVVVYPSN QTLKDYLSWR QADCHINNLY NTVFWALIQQ SGLTPVQAQG RLQGTLAADK NEILFSEFNI NYNNELPM

Tissue Specificity	Expressed in many tissues.
Function	Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.
Protein Name	Probable Trna(His Guanylyltransferase Induced In High Glucose-1 Ihg-1 Interphase Cytoplasmic Foci Protein 45 Trna-Histidine Guanylyltransferase
Database Links	Reactome: R-HSA-6782315
Cellular Localisation	Cytoplasm Mitochondrion Outer Membrane
Alternative Protein Names	Probable Trna(His Guanylyltransferase protein Induced In High Glucose-1 protein Ihg-1 protein Interphase Cytoplasmic Foci Protein 45 protein Trna-Histidine Guanylyltransferase protein THG1L protein ICF45 protein

Information sourced from Uniprot.org