• Human TGFR-2 protein (Active Recombinant) (C-hFc&His) (STJP001008)
  • Human TGFR-2 protein (Active Recombinant) (C-hFc&His) (STJP001008)
  • Human TGFR-2 protein (Active Recombinant) (C-hFc&His) (STJP001008)
  • Human TGFR-2 protein (Active Recombinant) (C-hFc&His) (STJP001008)

Human TGFR-2 protein (Active Recombinant) (C-hFc&His) (STJP001008)

SKU:
STJP001008

£68.50 - £206.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Active Recombinant-Human TGFR-2-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized recombinant human TGFB1 at 2 Mu g/mL (100 Mu L/well) can bind recombinant human TGFBR2 with a linear range of 1-5 ng/mL.
Gene Symbol: TGFBR2
Gene ID: 7048
Uniprot ID: TGFR2_HUMAN
Immunogen Region: Thr23-Asp159
Immunogen: Recombinant Human TGFR-2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Thr23-Asp159) of human TGFBR2 (Accession #NP_003233.4) fused with an Fc, 6×His tag at the C-terminus.
Post Translational Modifications Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. Isoform 1: Has transforming growth factor beta-activated receptor activity. Isoform 2: Has transforming growth factor beta-activated receptor activity. Isoform 3: Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1.
Protein Name Tgf-Beta Receptor Type-2
Tgfr-2
Tgf-Beta Type Ii Receptor
Transforming Growth Factor-Beta Receptor Type Ii
Tgf-Beta Receptor Type Ii
Tbetar-Ii
Database Links Reactome: R-HSA-2173788
Reactome: R-HSA-2173789
Reactome: R-HSA-2173791
Reactome: R-HSA-3304356
Reactome: R-HSA-3642279
Reactome: R-HSA-3645790
Reactome: R-HSA-3656532
Reactome: R-HSA-3656535
Reactome: R-HSA-5689603
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Isoform 3: Secreted
Alternative Protein Names Tgf-Beta Receptor Type-2 protein
Tgfr-2 protein
Tgf-Beta Type Ii Receptor protein
Transforming Growth Factor-Beta Receptor Type Ii protein
Tgf-Beta Receptor Type Ii protein
Tbetar-Ii protein
TGFBR2 protein

Information sourced from Uniprot.org

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