Human TFB2M protein (Recombinant) (His-Tag) (STJP017881)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human TFB2M-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TFB2M |
| Gene ID | 64216 |
| Uniprot ID | TFB2M_HUMAN |
| Accession Number | NP_071761.1 |
| Immunogen | Human |
| Immunogen Region | 20-396aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity. |
| Protein Name | Dimethyladenosine Transferase 2 - MitochondrialHepatitis C Virus Ns5a-Transactivated Protein 5Hcv Ns5a-Transactivated Protein 5Mitochondrial 12s Rrna Dimethylase 2Mitochondrial Transcription Factor B2H-MttfbH-Mttfb2Htfb2mMttfb2S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 2 |
| Database Links | Reactome: R-HSA-163282Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion |
| Alternative Protein Names | Dimethyladenosine Transferase 2 - Mitochondrial proteinHepatitis C Virus Ns5a-Transactivated Protein 5 proteinHcv Ns5a-Transactivated Protein 5 proteinMitochondrial 12s Rrna Dimethylase 2 proteinMitochondrial Transcription Factor B2 proteinH-Mttfb proteinH-Mttfb2 proteinHtfb2m proteinMttfb2 proteinS-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 2 proteinTFB2M proteinNS5ATP5 protein |
Information sourced from Uniprot.org