Human TFB1M protein (Recombinant) (His-Tag) (STJP017295)

Name: Human TFB1M protein (Recombinant) (His-Tag) (STJP017295)
SKU: STJP017295
Availability: InStock

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SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017295

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Short Description	Recombinant-Human TFB1M-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	TFB1M
Gene ID	51106
Uniprot ID	TFB1M_HUMAN
Accession Number	NP_057104
Immunogen	Human
Immunogen Region	28-346aa
Immunogen Sequence	QAAKQLSQN FLLDLRLTDK IVRKAGNLTN AYVYEVGPGP GGITRSILNA DVAELLVVEK DTRFIPGLQM LSDAAPGKLR IVHGDVLTFK VEKAFSESLK RPWEDDPPNV HIIGNLPFSV STPLIIKWLE NISCRDGPFV YGRTQMTLTF QKEVAERLAA NTGSKQRSRL SVMAQYLCNV RHIFTIPGQA FVPKPEVDVG VVHFTP

Tissue Specificity	Ubiquitously expressed.
Function	Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1583 and A1584) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
Protein Name	Dimethyladenosine Transferase 1 - Mitochondrial Mitochondrial 12s Rrna Dimethylase 1 Mitochondrial Transcription Factor B1 H-Mttfb H-Mttfb1 Htfb1m Mttfb1 S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 1
Database Links	Reactome: R-HSA-2151201 Reactome: R-HSA-6793080
Cellular Localisation	Mitochondrion
Alternative Protein Names	Dimethyladenosine Transferase 1 - Mitochondrial protein Mitochondrial 12s Rrna Dimethylase 1 protein Mitochondrial Transcription Factor B1 protein H-Mttfb protein H-Mttfb1 protein Htfb1m protein Mttfb1 protein S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 1 protein TFB1M protein CGI-75 protein

Information sourced from Uniprot.org