Human TESK1 protein (Recombinant) (N-His) (STJP015939)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TESK1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | TESK1 |
| Gene ID | 7016 |
| Uniprot ID | TESK1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser39-Leu318 |
Additional Info
| Post Translational Modifications | Autophosphorylated on serine and tyrosine residues. |
| Function | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity. Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1. Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin. Suppresses ciliogenesis via multiple pathways.phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. Probably plays a central role at and after the meiotic phase of spermatogenesis. |
| Protein Name | Dual Specificity Testis-Specific Protein Kinase 1Testicular Protein Kinase 1 |
| Database Links | Reactome: R-HSA-446388 |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosomeCell ProjectionLamellipodiumColocalizes With Spry4 In Vesicular Spots In The CytoplasmLocalized To F-Actin-Rich Lamellipodia At The Cell Periphery Following Fibronectin-Mediated Cell Adhesion Of Schwann Cells |
| Alternative Protein Names | Dual Specificity Testis-Specific Protein Kinase 1 proteinTesticular Protein Kinase 1 proteinTESK1 protein |
Information sourced from Uniprot.org