| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human TCF7L1-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | TCF7L1 |
| Gene ID: | 83439 |
| Uniprot ID: | TF7L1_HUMAN |
| Immunogen Region: | Asn351-Gly445 |
| Immunogen: | Homo sapiens (Human) |
| Function | Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance. |
| Protein Name | Transcription Factor 7-Like 1Hmg Box Transcription Factor 3Tcf-3 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3769402Reactome: R-HSA-4086398Reactome: R-HSA-4411364Reactome: R-HSA-4641265Reactome: R-HSA-8951430Reactome: R-HSA-9825892Reactome: R-HSA-9834899 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Transcription Factor 7-Like 1 proteinHmg Box Transcription Factor 3 proteinTcf-3 proteinTCF7L1 proteinTCF3 protein |
Information sourced from Uniprot.org