| Post Translational Modifications | Proteolytically processed by caspase-3 (CASP3). Autophosphorylated. Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2. |
| Function | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system. Also plays a role in the regulation of neuronal migration to the cortical plate. |
| Protein Name | Serine/Threonine-Protein Kinase Tao1Kinase From Chicken Homolog BHkfc-BMark KinaseMarkkProstate-Derived Sterile 20-Like Kinase 2Psk-2Psk2Prostate-Derived Ste20-Like Kinase 2Thousand And One Amino Acid Protein Kinase 1Taok1Htaok1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Serine/Threonine-Protein Kinase Tao1 proteinKinase From Chicken Homolog B proteinHkfc-B proteinMark Kinase proteinMarkk proteinProstate-Derived Sterile 20-Like Kinase 2 proteinPsk-2 proteinPsk2 proteinProstate-Derived Ste20-Like Kinase 2 proteinThousand And One Amino Acid Protein Kinase 1 proteinTaok1 proteinHtaok1 proteinTAOK1 proteinKIAA1361 proteinMAP3K16 proteinMARKK protein |
Information sourced from Uniprot.org
