Human TADA2A protein (Recombinant) (N-His) (STJP010735)

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STJP010735
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TADA2A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TADA2A
Gene ID: 6871
Uniprot ID: TAD2A_HUMAN
Immunogen Region: Met1-Gly443
Immunogen: Homo sapiens (Human)
Function Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Protein Name Transcriptional Adapter 2-Alpha
Transcriptional Adapter 2-Like
Ada2-Like Protein
Database Links Reactome: R-HSA-3214847
Reactome: R-HSA-9772755
Cellular Localisation Nucleus
Chromosome
Alternative Protein Names Transcriptional Adapter 2-Alpha protein
Transcriptional Adapter 2-Like protein
Ada2-Like Protein protein
TADA2A protein
TADA2L protein
KL04P protein

Information sourced from Uniprot.org

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