Human SYTL2 (Synaptotagmin Like Protein 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018804)
SPECIFICATIONS
General Information
| Short Description | This SYTL2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.113ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | SYTL2 |
| Gene ID | 54843 |
| Uniprot ID | SYTL2_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells. |
| Post Translational Modifications | Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A. |
| Function | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. |
| Protein Name | Synaptotagmin-Like Protein 2Breast Cancer-Associated Antigen Sga-72mExophilin-4 |
| Database Links | Reactome: R-HSA-9824585 |
| Cellular Localisation | Isoform 1: CytoplasmCell MembraneRecruited On Vesicular Structures In Cytotoxic T-Lymphocytes (Ctl) By Rab27aIsoform 4: Cell MembraneIn The Pancreatic Alpha Cells Distributed In Both Peripheral And Anterior RegionsLocalizes On The Glucagon Granules In The Cell Periphery |
| Alternative ELISA Names | Synaptotagmin-Like Protein 2 ELISA kitBreast Cancer-Associated Antigen Sga-72m ELISA kitExophilin-4 ELISA kitSYTL2 ELISA kitKIAA1597 ELISA kitSGA72M ELISA kitSLP2 ELISA kitSLP2A ELISA kit |
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Information sourced from Uniprot.org