| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.113ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description : | This SUZ12 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | SUZ12 |
| Gene ID: | 23512 |
| Uniprot ID: | SUZ12_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Overexpressed in breast and colon cancer. |
| Post Translational Modifications | Sumoylated, probably by PIAS2. |
| Function | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
| Protein Name | Polycomb Protein Suz12Chromatin Precipitated E2f Target 9 ProteinChet 9 ProteinJoined To Jazf1 ProteinSuppressor Of Zeste 12 Protein Homolog |
| Database Links | Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214841Reactome: R-HSA-4551638Reactome: R-HSA-5617472Reactome: R-HSA-8943724Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9710421 |
| Cellular Localisation | NucleusLocalizes To Chromatin As Part Of The Prc2 Complex |
| Alternative ELISA Names | Polycomb Protein Suz12 ELISA kitChromatin Precipitated E2f Target 9 Protein ELISA kitChet 9 Protein ELISA kitJoined To Jazf1 Protein ELISA kitSuppressor Of Zeste 12 Protein Homolog ELISA kitSUZ12 ELISA kitCHET9 ELISA kitJJAZ1 ELISA kitKIAA0160 ELISA kit |
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Information sourced from Uniprot.org
