Human SUZ12 protein (Recombinant) (N-His) (STJP008794)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SUZ12-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SUZ12 |
| Gene ID | 23512 |
| Uniprot ID | SUZ12_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys587-Gly691 |
Additional Info
| Post Translational Modifications | Sumoylated, probably by PIAS2. |
| Function | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
| Protein Name | Polycomb Protein Suz12Chromatin Precipitated E2f Target 9 ProteinChet 9 ProteinJoined To Jazf1 ProteinSuppressor Of Zeste 12 Protein Homolog |
| Database Links | Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214841Reactome: R-HSA-4551638Reactome: R-HSA-5617472Reactome: R-HSA-8943724Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9710421 |
| Cellular Localisation | NucleusLocalizes To Chromatin As Part Of The Prc2 Complex |
| Alternative Protein Names | Polycomb Protein Suz12 proteinChromatin Precipitated E2f Target 9 Protein proteinChet 9 Protein proteinJoined To Jazf1 Protein proteinSuppressor Of Zeste 12 Protein Homolog proteinSUZ12 proteinCHET9 proteinJJAZ1 proteinKIAA0160 protein |
Information sourced from Uniprot.org