| Tissue Specificity | Expressed predominantly in liver. |
| Post Translational Modifications | Polymeric chains can be formed through Lys-11 cross-linking. Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function. |
| Function | Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX. |
| Protein Name | Small Ubiquitin-Related Modifier 3Sumo-3Smt3 Homolog 1Sumo-2Ubiquitin-Like Protein Smt3aSmt3a |
| Database Links | Reactome: R-HSA-3065676Reactome: R-HSA-3065678Reactome: R-HSA-3065679Reactome: R-HSA-3108214Reactome: R-HSA-3232118Reactome: R-HSA-3899300Reactome: R-HSA-4090294Reactome: R-HSA-4551638Reactome: R-HSA-4615885Reactome: R-HSA-4755510Reactome: R-HSA-5696395 |
| Cellular Localisation | CytoplasmNucleusPml Body |
| Alternative Protein Names | Small Ubiquitin-Related Modifier 3 proteinSumo-3 proteinSmt3 Homolog 1 proteinSumo-2 proteinUbiquitin-Like Protein Smt3a proteinSmt3a proteinSUMO3 proteinSMT3A proteinSMT3H1 protein |
Information sourced from Uniprot.org
