| Tissue Specificity | Ubiquitously expressed in various human primary cells and tumor cell lines. |
| Post Translational Modifications | Glycosylation is required for cell surface expression. Phosphorylated predominantly on Ser residues. |
| Function | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels. Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry. Involved in enamel formation. |
| Protein Name | Stromal Interaction Molecule 1 |
| Database Links | Reactome: R-HSA-139853Reactome: R-HSA-5578775Reactome: R-HSA-983695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneCytoplasmCytoskeletonSarcoplasmic ReticulumTranslocates From The Endoplasmic Reticulum To The Cell Membrane In Response To A Depletion Of Intracellular Calcium And Is Detected At Punctae Corresponding To Junctions Between The Endoplasmic Reticulum And The Cell MembraneAssociated With The Microtubule Network At The Growing Distal Tip Of MicrotubulesColocalizes With Orai1 At The Cell MembraneColocalizes Preferentially With Casq1 At Endoplasmic Reticulum In Response To A Depletion Of Intracellular Calcium |
| Alternative Protein Names | Stromal Interaction Molecule 1 proteinSTIM1 proteinGOK protein |
Information sourced from Uniprot.org
