Human STEAP3 protein (Recombinant) (N-His) (STJP008217)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human STEAP3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | STEAP3 |
| Gene ID | 55240 |
| Uniprot ID | STEA3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys30-Arg207 |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner. Glycosylated. |
| Function | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate. Can also reduce Cu(2+) to Cu(1+). Mediates efficient transferrin-dependent iron uptake in erythroid cells. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. |
| Protein Name | Metalloreductase Steap3Dudulin-2Six-Transmembrane Epithelial Antigen Of Prostate 3Tumor Suppressor-Activated Pathway Protein 6Htsap6PhydeHphyde |
| Database Links | Reactome: R-HSA-6803204Reactome: R-HSA-9013148Reactome: R-HSA-9013405Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9035034Reactome: R-HSA-917977 |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane ProteinLocalizes To Vesicular-Like Structures At The Plasma Membrane And Around The Nucleus |
| Alternative Protein Names | Metalloreductase Steap3 proteinDudulin-2 proteinSix-Transmembrane Epithelial Antigen Of Prostate 3 proteinTumor Suppressor-Activated Pathway Protein 6 proteinHtsap6 proteinPhyde proteinHphyde proteinSTEAP3 proteinTSAP6 protein |
Information sourced from Uniprot.org