Human Stathmin 1 (Stathmin 1) Antibody Pair (STJAP00824)
General Information
| Short Description | This Stathmin 1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R31-3G-9/R25-1X-6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | STMN1 |
| Gene ID | 3925 |
| Uniprot ID | STMN1_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. |
| Post Translational Modifications | Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization. Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. |
| Function | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. |
| Protein Name | StathminLeukemia-Associated Phosphoprotein P18MetablastinOncoprotein 18Op18Phosphoprotein P19Pp19ProsolinProtein Pr22Pp17 |
| Database Links | Reactome: R-HSA-1251985 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Pair Names | Stathmin antibody pairLeukemia-Associated Phosphoprotein P18 antibody pairMetablastin antibody pairOncoprotein 18 antibody pairOp18 antibody pairPhosphoprotein P19 antibody pairPp19 antibody pairProsolin antibody pairProtein Pr22 antibody pairPp17 antibody pairSTMN1 antibody pairC1orf215 antibody pairLAP18 antibody pairOP18 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human Stathmin 1 (Stathmin 1) Antibody Pair (STJAP00824)
This antibody pair is designed to detect human Stathmin 1 (UniProt P16949) and has confirmed reactivity with human samples only. It is intended for research use only.
This antibody pair has been validated for use in ELISA. Both the capture and detection antibodies are supplied unconjugated, so researchers will need to label the detection antibody or use an appropriate secondary detection system.
Both antibodies are rabbit-derived monoclonal IgGs. The clone IDs are R31-3G-9 and R25-1X-6, and both were raised against a recombinant protein immunogen.
Both antibodies are supplied at 1 mg/mL in 0.01M PBS at pH 7.2, and each has been affinity purified. Working dilutions should be determined by the end user through titration.
The antibodies should be stored at 4°C for short-term use. For long-term storage, they should be aliquoted and kept at -20°C. Repeated freeze/thaw cycles should be avoided to maintain activity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.