Human STAMP2/STEAP4 protein (Recombinant) (His-Tag) (STJP018692)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human STAMP2/STEAP4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STEAP4 |
| Gene ID | 79689 |
| Uniprot ID | STEA4_HUMAN |
| Accession Number | NP_078912 |
| Immunogen | Human |
| Immunogen Region | 1-152aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages. |
| Function | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate. Can also reduce Cu(2+) to Cu(1+). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation. |
| Protein Name | Metalloreductase Steap4Six-Transmembrane Epithelial Antigen Of Prostate 4Sixtransmembrane Protein Of Prostate 2Tumor Necrosis Factor - Alpha-Induced Protein 9 |
| Database Links | Reactome: R-HSA-917977 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneEarly Endosome Membrane |
| Alternative Protein Names | Metalloreductase Steap4 proteinSix-Transmembrane Epithelial Antigen Of Prostate 4 proteinSixtransmembrane Protein Of Prostate 2 proteinTumor Necrosis Factor - Alpha-Induced Protein 9 proteinSTEAP4 proteinSTAMP2 proteinTNFAIP9 protein |
Information sourced from Uniprot.org