Human ST3GAL1 protein (Recombinant) (N-His) (STJP016241)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ST3GAL1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | ST3GAL1 |
| Gene ID | 6482 |
| Uniprot ID | SIA4A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr35-Arg340 |
Additional Info
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. |
| Function | A beta-galactoside alpha2->3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid.Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response. Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser. Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively. |
| Protein Name | Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 1Alpha 2 -3-St 1Beta-Galactoside Alpha-2 -3-Sialyltransferase 1Gal-Nac6sGal-Beta-1 -3-Galnac-Alpha-2 -3-SialyltransferaseMonosialoganglioside SialyltransferaseSiatflSt3gal ISt3galiSt3gala.1St3oSialyltransferase 4aSiat4-A |
| Database Links | Reactome: R-HSA-2022854Reactome: R-HSA-4085001Reactome: R-HSA-9683673Reactome: R-HSA-9694548Reactome: R-HSA-9694719Reactome: R-HSA-977068 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinTrans-Golgi Network MembraneSecretedMembrane-Bound Form In Medial And Trans Cisternae Of GolgiSecreted Into The Body Fluid |
| Alternative Protein Names | Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 1 proteinAlpha 2 -3-St 1 proteinBeta-Galactoside Alpha-2 -3-Sialyltransferase 1 proteinGal-Nac6s proteinGal-Beta-1 -3-Galnac-Alpha-2 -3-Sialyltransferase proteinMonosialoganglioside Sialyltransferase proteinSiatfl proteinSt3gal I proteinSt3gali proteinSt3gala.1 proteinSt3o proteinSialyltransferase 4a proteinSiat4-A proteinST3GAL1 proteinSIAT4 proteinSIAT4A protein |
Information sourced from Uniprot.org