Human SSBP1 protein (Recombinant) (His-Tag) (STJP018135)

Name: Human SSBP1 protein (Recombinant) (His-Tag) (STJP018135)
SKU: STJP018135
Availability: InStock

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SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP018135

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Short Description	Recombinant-Human SSBP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% Glycerol, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	SSBP1
Gene ID	6742
Uniprot ID	SSBP_HUMAN
Accession Number	NP_003134
Immunogen	Human
Immunogen Region	17-148aa
Immunogen Sequence	ESETTTS LVLERSLNRV HLLGRVGQDP VLRQVEGKNP VTIFSLATNE MWRSGDSEVY QLGDVSQKTT WHRISVFRPG LRDVAYQYVK KGSRIYLEGK IDYGEYMDKN NVRRQATTII ADNIIFLSDQ TKEKE

Tissue Specificity	Expressed in retinal ganglion cells, photoreceptors, pigmented epithelium and fibroblasts (at protein level).
Function	Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair.
Protein Name	Single-Stranded Dna-Binding Protein - Mitochondrial Mt-Ssb Mtssb Pwp1-Interacting Protein 17
Database Links	Reactome: R-HSA-2151201 Reactome: R-HSA-9837999 Reactome: R-HSA-9913635
Cellular Localisation	Mitochondrion Mitochondrion Matrix Mitochondrion Nucleoid
Alternative Protein Names	Single-Stranded Dna-Binding Protein - Mitochondrial protein Mt-Ssb protein Mtssb protein Pwp1-Interacting Protein 17 protein SSBP1 protein SSBP protein

Information sourced from Uniprot.org