Human SRSF3 protein (Recombinant) (N-GST & C-His) (STJP016023)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SRSF3-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | SRSF3 |
| Gene ID | 6428 |
| Uniprot ID | SRSF3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | His2-Glu84 |
Additional Info
| Function | Splicing factor, which binds the consensus motif 5'-CACUAUCACUACC-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway).enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 3Pre-Mrna-Splicing Factor Srp20Splicing Factor - Arginine/Serine-Rich 3 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmRecruited To Nuclear Speckles Following Interaction With Ythdc1 |
| Alternative Protein Names | Serine/Arginine-Rich Splicing Factor 3 proteinPre-Mrna-Splicing Factor Srp20 proteinSplicing Factor - Arginine/Serine-Rich 3 proteinSRSF3 proteinSFRS3 proteinSRP20 protein |
Information sourced from Uniprot.org