| Function | Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 1Alternative-Splicing Factor 1Asf-1Splicing Factor - Arginine/Serine-Rich 1Pre-Mrna-Splicing Factor Sf2 - P33 Subunit |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856 |
| Cellular Localisation | CytoplasmNucleus SpeckleIn Nuclear SpecklesShuttles Between The Nucleus And The CytoplasmNuclear Import Is Mediated Via Interaction With Tnpo3 |
| Alternative Protein Names | Serine/Arginine-Rich Splicing Factor 1 proteinAlternative-Splicing Factor 1 proteinAsf-1 proteinSplicing Factor - Arginine/Serine-Rich 1 proteinPre-Mrna-Splicing Factor Sf2 - P33 Subunit proteinSRSF1 proteinASF proteinSF2 proteinSF2P33 proteinSFRS1 proteinOK proteinSW-cl.3 protein |
Information sourced from Uniprot.org
