Human SP-D protein (Recombinant) (His-Tag) (STJP018827)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human SP-D-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SFTPD |
| Gene ID | 6441 |
| Uniprot ID | SFTPD_HUMAN |
| Accession Number | NP_003010.4 |
| Immunogen | Human |
| Immunogen Region | 224-375aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes). |
| Post Translational Modifications | The N-terminus is blocked. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages. |
| Function | Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. |
| Protein Name | Pulmonary Surfactant-Associated Protein DPsp-DSp-DCollectin-7Lung Surfactant Protein D |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-168179Reactome: R-HSA-198933Reactome: R-HSA-391160Reactome: R-HSA-5683826Reactome: R-HSA-5686938Reactome: R-HSA-5688849Reactome: R-HSA-5688890Reactome: R-HSA-9692916Reactome: R-HSA-9705671 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixSurface Film |
| Alternative Protein Names | Pulmonary Surfactant-Associated Protein D proteinPsp-D proteinSp-D proteinCollectin-7 proteinLung Surfactant Protein D proteinSFTPD proteinCOLEC7 proteinPSPD proteinSFTP4 protein |
Information sourced from Uniprot.org