Human SORBS3 protein (Recombinant) (His-Tag) (STJP018604)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human SORBS3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SORBS3 |
| Gene ID | 10174 |
| Uniprot ID | VINEX_HUMAN |
| Accession Number | NP_001018003 |
| Immunogen | Human |
| Immunogen Region | 1-329aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver. |
| Post Translational Modifications | Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading. |
| Function | Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. |
| Protein Name | VinexinSh3-Containing Adapter Molecule 1Scam-1Sorbin And Sh3 Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | Isoform Alpha: Cell JunctionCytoplasmCytoskeletonLocalized At Cell-Extracellular Matrix JunctionsBoth Isoforms Were Localized At Focal Adhesion And Cell-Cell Adhesion SitesIsoform Beta: Cell JunctionNucleusVinexin Beta Was Also Found In The Nucleus |
| Alternative Protein Names | Vinexin proteinSh3-Containing Adapter Molecule 1 proteinScam-1 proteinSorbin And Sh3 Domain-Containing Protein 3 proteinSORBS3 proteinSCAM1 protein |
Information sourced from Uniprot.org