Human SNX5 protein (Recombinant) (His-Tag) (STJP019148)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human SNX5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNX5 |
| Gene ID | 27131 |
| Uniprot ID | SNX5_HUMAN |
| Accession Number | NP_689413 |
| Immunogen | Human |
| Immunogen Region | 1-404aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMAAVPEL LQQQEEDRSK LRSVSVDLNV DPSLQIDIPD ALSERDKVKF TVHTKTTLPT FQSPEFSVTR QHEDFVWLHD TLIETTDYAG LIIPPAPTKP DFDGPREKMQ KLGEGEGSMT KEEFAKMKQE LEAEYLAVFK KTVSSHEVFL QRLSSHPVLS KDRNFHVFLE YDQDLSVRRK NTKEMFGGFF KSVVKSADEV LFTGVKEV |
Additional Info
| Function | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation.the function involves PIP5K1C isoform 3 and is retromer-independent. Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation.inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. Plays a role in macropinocytosis. |
| Protein Name | Sorting Nexin-5 |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | EndosomeEarly EndosomeEarly Endosome MembranePeripheral Membrane ProteinCytoplasmic SideCell MembraneCytoplasmic Vesicle MembraneCytoplasmCell ProjectionPhagocytic CupRuffleRecruited To The Plasma Membrane After Egf StimulationWhich Leads To Increased Levels Of Phosphatidylinositol 34-Bisphosphate (Pdtins(34)P2)Detected On MacropinosomesTargeted To Membrane Ruffles In Response To Egfr Stimulation |
| Alternative Protein Names | Sorting Nexin-5 proteinSNX5 protein |
Information sourced from Uniprot.org