Human SNIP1 protein (Recombinant) (His-Tag) (STJP017206)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human SNIP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% Glycerol, 100mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNIP1 |
| Gene ID | 79753 |
| Uniprot ID | SNIP1_HUMAN |
| Accession Number | NP_078976 |
| Immunogen | Human |
| Immunogen Region | 258-396aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous, with highest expression in heart and skeletal muscle. |
| Post Translational Modifications | Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex. |
| Function | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. |
| Protein Name | Smad Nuclear-Interacting Protein 1Fha Domain-Containing Protein Snip1 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Smad Nuclear-Interacting Protein 1 proteinFha Domain-Containing Protein Snip1 proteinSNIP1 protein |
Information sourced from Uniprot.org