Human SMDT1 protein (Recombinant) (N-GST & C-His) (STJP014831)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SMDT1-N-GST & C-His protein was developed from e.coli and has a target region of N-GST & C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | SMDT1 |
| Gene ID | 91689 |
| Uniprot ID | EMRE_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asp107 |
Additional Info
| Function | Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 with the calcium-conducting subunit MCU. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling. |
| Protein Name | Essential Mcu Regulator - MitochondrialSingle-Pass Membrane Protein With Aspartate-Rich Tail 1 - Mitochondrial |
| Database Links | Reactome: R-HSA-8949215Reactome: R-HSA-8949664Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane ProteinMaip1 Is Required To Assist Sorting Of Emre/Smdt1 Into Mitochondrion By Protecting Emre/Smdt1 Against Protein Degradation By Yme1l1Thereby Ensuring Smdt1/Emre Maturation By The Mitochondrial Processing Peptidase (Pmpca And Pmpcb) |
| Alternative Protein Names | Essential Mcu Regulator - Mitochondrial proteinSingle-Pass Membrane Protein With Aspartate-Rich Tail 1 - Mitochondrial proteinSMDT1 proteinC22orf32 proteinEMRE protein |
Information sourced from Uniprot.org