Human SLCO1B1/LST-1/OATP-2 protein (Recombinant) (N-His) (STJP006725)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLCO1B1/LST-1/OATP-2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SLCO1B1 |
| Gene ID | 10599 |
| Uniprot ID | SO1B1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Phe426-Phe537 |
Additional Info
| Function | Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop. Involved in the clearance of endogenous and exogenous substrates from the liver. Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins), such as pravastatin and pitavastatin, a clinically important class of hypolipidemic drugs. May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drug methotrexate. May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver. Shows a pH-sensitive substrate specificity towards prostaglandin E2 and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. |
| Protein Name | Solute Carrier Organic Anion Transporter Family Member 1b1Slco1b1Liver-Specific Organic Anion Transporter 1Lst-1Oatp-COrganic Anion Transporter Slc21a6Sodium-Independent Organic Anion-Transporting Polypeptide 2Oatp-2Solute Carrier Family 21 Member 6 |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-189483Reactome: R-HSA-5619110Reactome: R-HSA-879518Reactome: R-HSA-9754706 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinBasal Cell MembraneDetected In Basolateral Membranes Of HepatocytesLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Protein Names | Solute Carrier Organic Anion Transporter Family Member 1b1 proteinSlco1b1 proteinLiver-Specific Organic Anion Transporter 1 proteinLst-1 proteinOatp-C proteinOrganic Anion Transporter Slc21a6 proteinSodium-Independent Organic Anion-Transporting Polypeptide 2 proteinOatp-2 proteinSolute Carrier Family 21 Member 6 proteinSLCO1B1 proteinLST1 proteinOATP1B1 proteinOATP2 proteinOATPC proteinSLC21A6 protein |
Information sourced from Uniprot.org