Human SLC9A9 protein (Recombinant) (N-His-KSI) (STJP011013)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC9A9-N-His-KSI protein was developed from e.coli for the region N-His-KSI. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SLC9A9 |
| Gene ID | 285195 |
| Uniprot ID | SL9A9_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | [Arg67-Lys126] & [Leu487-Asn645] |
Additional Info
| Function | Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters. Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain. Regulates synaptic transmission by regulating the luminal pH of axonal endosomes. Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages. Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH. |
| Protein Name | Sodium/Hydrogen Exchanger 9Na(+/H(+ Exchanger 9Nhe-9Solute Carrier Family 9 Member 9 |
| Database Links | Reactome: R-HSA-425986Reactome: R-HSA-5619052 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneRecycling Endosome MembraneCell MembraneCytoplasmic VesiclePhagosome MembraneLocalized To The Plasma Membrane In Inner Ear Hair Cell Bundle |
| Alternative Protein Names | Sodium/Hydrogen Exchanger 9 proteinNa(+/H(+ Exchanger 9 proteinNhe-9 proteinSolute Carrier Family 9 Member 9 proteinSLC9A9 proteinNHE9 proteinNbla00118 protein |
Information sourced from Uniprot.org