Human SLC8A1 protein (Recombinant) (N-His) (STJP007833)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC8A1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SLC8A1 |
| Gene ID | 6546 |
| Uniprot ID | NAC1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser407-Glu718 |
Additional Info
| Function | Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. |
| Protein Name | Sodium/Calcium Exchanger 1Na(+/Ca(2+-Exchange Protein 1Solute Carrier Family 8 Member 1 |
| Database Links | Reactome: R-HSA-418359Reactome: R-HSA-425561Reactome: R-HSA-5578775 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Sodium/Calcium Exchanger 1 proteinNa(+/Ca(2+-Exchange Protein 1 proteinSolute Carrier Family 8 Member 1 proteinSLC8A1 proteinCNC proteinNCX1 protein |
Information sourced from Uniprot.org