Human SLC4A4 protein (Recombinant) (C-His) (STJP016041)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC4A4-C-His protein was developed from e.coli for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | SLC4A4 |
| Gene ID | 8671 |
| Uniprot ID | S4A4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Tyr610-Ile692&Val746-Trp779 |
Additional Info
| Post Translational Modifications | Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase.phosphorylation seems to inhibit SLC4A4 activity. N-glycosylated. May not be necessary for the transporter basic functions. |
| Function | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. |
| Protein Name | Electrogenic Sodium Bicarbonate Cotransporter 1Sodium Bicarbonate CotransporterNa(+/Hco3(- CotransporterSolute Carrier Family 4 Member 4Knbc1 |
| Database Links | Reactome: R-HSA-425381Reactome: R-HSA-5619054 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Protein Names | Electrogenic Sodium Bicarbonate Cotransporter 1 proteinSodium Bicarbonate Cotransporter proteinNa(+/Hco3(- Cotransporter proteinSolute Carrier Family 4 Member 4 proteinKnbc1 proteinSLC4A4 proteinNBC proteinNBC1 proteinNBCE1 protein |
Information sourced from Uniprot.org