Human SLC22A5 protein (Recombinant) (N-His-SUMO) (STJP007914)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC22A5-N-His-SUMO protein was developed from e.coli for the region N-His-SUMO. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SLC22A5 |
| Gene ID | 6584 |
| Uniprot ID | S22A5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr45-Lys141 |
Additional Info
| Post Translational Modifications | Glycosylated. Glycosylation affects the expression levels. Isoform 3: Not glycosylated. |
| Function | Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 11.3. In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from B.subtilis which induces cytoprotective heat shock proteins contributing to intestinal homeostasis. May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Isoform 3: Retained in the ER, unable to perform carnitine uptake. |
| Protein Name | Organic Cation/Carnitine Transporter 2High-Affinity Sodium-Dependent Carnitine CotransporterSolute Carrier Family 22 Member 5 |
| Database Links | Reactome: R-HSA-200425Reactome: R-HSA-549127Reactome: R-HSA-5619053 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneBasal Cell MembraneIn Intestinal CellsApical Expression Is Induced By TnfLocalized To The Basal Membrane Of Sertoli CellsIsoform 3: Endoplasmic Reticulum |
| Alternative Protein Names | Organic Cation/Carnitine Transporter 2 proteinHigh-Affinity Sodium-Dependent Carnitine Cotransporter proteinSolute Carrier Family 22 Member 5 proteinSLC22A5 proteinOCTN2 protein |
Information sourced from Uniprot.org