Human SLC1A1 protein (Recombinant) (N-His) (STJP004731)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC1A1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SLC1A1 |
| Gene ID | 6505 |
| Uniprot ID | EAA3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser115-Gly209 |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport.this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5. |
| Protein Name | Excitatory Amino Acid Transporter 3Excitatory Amino-Acid Carrier 1Neuronal And Epithelial Glutamate TransporterSodium-Dependent Glutamate/Aspartate Transporter 3Solute Carrier Family 1 Member 1 |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-425393Reactome: R-HSA-5619067 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneSynapseSynaptosomeEarly Endosome MembraneLate Endosome MembraneRecycling Endosome Membrane |
| Alternative Protein Names | Excitatory Amino Acid Transporter 3 proteinExcitatory Amino-Acid Carrier 1 proteinNeuronal And Epithelial Glutamate Transporter proteinSodium-Dependent Glutamate/Aspartate Transporter 3 proteinSolute Carrier Family 1 Member 1 proteinSLC1A1 proteinEAAC1 proteinEAAT3 proteinHEAAC1 protein |
Information sourced from Uniprot.org