Human SLC19A1 protein (Recombinant) (N-His) (STJP004704)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC19A1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SLC19A1 |
| Gene ID | 6573 |
| Uniprot ID | S19A1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu455-Gln591 |
Additional Info
| Function | Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses. Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also mediates the import of antifolate drug methotrexate. 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity. |
| Protein Name | Reduced Folate TransporterFoltCyclic Dinucleotide -Anion Antiporter Slc19a1Folate -Anion Antiporter Slc19a1Intestinal Folate Carrier 1Ifc-1Placental Folate TransporterReduced Folate Carrier ProteinRfcHrfcReduced Folate Transporter 1Rft-1Solute Carrier Family 19 Member 1Hslc19a1 |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneBasolateral Cell Membrane |
| Alternative Protein Names | Reduced Folate Transporter proteinFolt proteinCyclic Dinucleotide -Anion Antiporter Slc19a1 proteinFolate -Anion Antiporter Slc19a1 proteinIntestinal Folate Carrier 1 proteinIfc-1 proteinPlacental Folate Transporter proteinReduced Folate Carrier Protein proteinRfc proteinHrfc proteinReduced Folate Transporter 1 proteinRft-1 proteinSolute Carrier Family 19 Member 1 proteinHslc19a1 proteinSLC19A1 proteinFLOT1 proteinRFC1 protein |
Information sourced from Uniprot.org