Human SLAMF2/CD48 protein (Recombinant) (C-His) (STJP001035)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human SLAMF2/CD48 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln27-Ser220) of human CD48/SLAMF2/BCM1 (Accession #NP_001769.2) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human SLAMF2/CD48-C-His protein was developed in hek293 cells using the region Gln27-Ser220. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD48 at 5 Mu g/mL (100 Mu L/well) can bind recombinant human CD244 with a linear range of 0.2-1 Mu g/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CD48 |
| Gene ID | 962 |
| Uniprot ID | CD48_HUMAN |
| Immunogen | Recombinant Human SLAMF2/CD48 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln27-Ser220) of human CD48/SLAMF2/BCM1 (Accession #NP_001769.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Gln27-Ser220 |
| Immunogen Sequence | QGHLVHMTVVSGSNVTLNIS ESLPENYKQLTWFYTFDQKI VEWDSRKSKYFESKFKGRVR LDPQSGALYISKVQKEDNST YIMRVLKKTGNEQEWKIKLQ VLDPVPKPVIKIEKIEDMDD NCYLKLSCVIPGESVNYTWY GDKRPFPKELQNSVLETTLM PHNYSRCYTCQVSNSVSSKN GTVCLSPPCTLARS |
Additional Info
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenB-Lymphocyte Activation Marker Blast-1Bcm1 Surface AntigenLeukocyte Antigen Mem-102Slam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Tct.1Cd Antigen Cd48 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftSecreted |
| Alternative Protein Names | Cd48 Antigen proteinB-Lymphocyte Activation Marker Blast-1 proteinBcm1 Surface Antigen proteinLeukocyte Antigen Mem-102 proteinSlam Family Member 2 proteinSlamf2 proteinSignaling Lymphocytic Activation Molecule 2 proteinTct.1 proteinCd Antigen Cd48 proteinCD48 proteinBCM1 proteinBLAST1 protein |
Information sourced from Uniprot.org