Human SIRT5 protein (Recombinant) (N-His) (STJP007442)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SIRT5-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SIRT5 |
| Gene ID | 23408 |
| Uniprot ID | SIR5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met40-Ser310 |
Additional Info
| Function | NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity.however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. |
| Protein Name | Nad-Dependent Protein Deacylase Sirtuin-5 - MitochondrialRegulatory Protein Sir2 Homolog 5Sir2-Like Protein 5 |
| Database Links | Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion MatrixMitochondrion Intermembrane SpaceCytoplasmCytosolNucleusMainly MitochondrialAlso Present ExtramitochondriallyWith A Fraction Present In The Cytosol And Very Small Amounts Also Detected In The NucleusIsoform 1: CytoplasmMitochondrionIsoform 2: Mitochondrion |
| Alternative Protein Names | Nad-Dependent Protein Deacylase Sirtuin-5 - Mitochondrial proteinRegulatory Protein Sir2 Homolog 5 proteinSir2-Like Protein 5 proteinSIRT5 proteinSIR2L5 protein |
Information sourced from Uniprot.org