Human Siglec-5/CD170 protein (Recombinant) (No tag) (STJP002940)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenRecombinant Human Siglec-5/CD170 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys18-Val437) of human Siglec-5/CD170 (Accession #NP_003821.1) fused with a His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Siglec-5/CD170-No tag protein was developed in e.coli using the region Lys18-Val437. For use in research applications. |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | SIGLEC5 |
| Gene ID | 8778 |
| Uniprot ID | SIGL5_HUMAN |
| Immunogen | Recombinant Human Siglec-5/CD170 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys18-Val437) of human Siglec-5/CD170 (Accession #NP_003821.1) fused with a His tag at the C-terminus. |
| Immunogen Region | Lys18-Val437 |
| Immunogen Sequence | KPVRKRAVSEIQLMHNLGKH LASMERMQWLRRKLQDMHNF VSLGVQMAARDGSHQKPTKK EENVLVDGNPKSLGEGDKAD VDVLVKSKSQ |
Additional Info
| Tissue Specificity | Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 5Siglec-5Cd33 Antigen-Like 2Obesity-Binding Protein 2Ob-Bp2Ob-Binding Protein 2Cd Antigen Cd170 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Sialic Acid-Binding Ig-Like Lectin 5 proteinSiglec-5 proteinCd33 Antigen-Like 2 proteinObesity-Binding Protein 2 proteinOb-Bp2 proteinOb-Binding Protein 2 proteinCd Antigen Cd170 proteinSIGLEC5 proteinCD33L2 proteinOBBP2 protein |
Information sourced from Uniprot.org