Human SHPRH protein (Recombinant) (N-His) (STJP016289)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SHPRH-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | SHPRH |
| Gene ID | 257218 |
| Uniprot ID | SHPRH_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu1381-Glu1683 |
Additional Info
| Function | E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. |
| Protein Name | E3 Ubiquitin-Protein Ligase ShprhRing-Type E3 Ubiquitin Transferase ShprhSnf2 - Histone-Linker - Phd And Ring Finger Domain-Containing Helicase |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Shprh proteinRing-Type E3 Ubiquitin Transferase Shprh proteinSnf2 - Histone-Linker - Phd And Ring Finger Domain-Containing Helicase proteinSHPRH proteinKIAA2023 protein |
Information sourced from Uniprot.org