Human SHP/NR0B2 protein (Recombinant) (N-His) (STJP005452)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SHP/NR0B2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NR0B2 |
| Gene ID | 8431 |
| Uniprot ID | NR0B2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Arg257 |
Additional Info
| Post Translational Modifications | Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors. |
| Function | Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with which it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism. Regulates the circadian expression of cytochrome P450 (CYP) enzymes. Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14. |
| Protein Name | Nuclear Receptor Subfamily 0 Group B Member 2Orphan Nuclear Receptor ShpSmall Heterodimer Partner |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Neurod1 In The Nucleus |
| Alternative Protein Names | Nuclear Receptor Subfamily 0 Group B Member 2 proteinOrphan Nuclear Receptor Shp proteinSmall Heterodimer Partner proteinNR0B2 proteinSHP protein |
Information sourced from Uniprot.org