Human SGPL1 protein (Recombinant) (N-His) (STJP003432)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SGPL1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SGPL1 |
| Gene ID | 8879 |
| Uniprot ID | SGPL1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln239-Arg493 |
Additional Info
| Function | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance. |
| Protein Name | Sphingosine-1-Phosphate Lyase 1S1plSp-Lyase 1Spl 1HsplSphingosine-1-Phosphate Aldolase |
| Database Links | Reactome: R-HSA-9845614 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iii Membrane ProteinCytoplasmic Side |
| Alternative Protein Names | Sphingosine-1-Phosphate Lyase 1 proteinS1pl proteinSp-Lyase 1 proteinSpl 1 proteinHspl proteinSphingosine-1-Phosphate Aldolase proteinSGPL1 proteinKIAA1252 protein |
Information sourced from Uniprot.org