| Post Translational Modifications | Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320. |
| Function | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. |
| Protein Name | Serine/Threonine-Protein Kinase Sgk3Cytokine-Independent Survival KinaseSerum/Glucocorticoid-Regulated Kinase 3Serum/Glucocorticoid-Regulated Kinase-Like |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cytoplasmic VesicleEarly EndosomeRecycling EndosomeEndosomal Localization Is A Prerequisite For Complete Kinase ActivityIt Is Essential For Its Colocalization With The Kinase Responsible For Phosphorylating Ser-486 Thus Allowing Pdpk1 Phosphorylation Of Thr-320 Resulting In Complete Activation Of Sgk3Localized In Vesicle-Like Structures And In The Early EndosomeColocalizes With Slc9a3/Nhe3 In The Recycling Endosomes |
| Alternative Protein Names | Serine/Threonine-Protein Kinase Sgk3 proteinCytokine-Independent Survival Kinase proteinSerum/Glucocorticoid-Regulated Kinase 3 proteinSerum/Glucocorticoid-Regulated Kinase-Like proteinSGK3 proteinCISK proteinSGKL protein |
Information sourced from Uniprot.org
