Human SETD7 (SET Domain Containing Protein 7) Sandwich ELISA Kit (STJE0012115)
SPECIFICATIONS
General Information
| Short Description | This SETD7 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.054ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | SETD7 |
| Gene ID | 80854 |
| Uniprot ID | SETD7_HUMAN |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Widely expressed. Expressed in pancreatic islets. |
| Post Translational Modifications | |
| Function | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the KR-STA-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS. |
| Protein Name | Histone-Lysine N-Methyltransferase Setd7Histone H3-K4 Methyltransferase Setd7H3-K4-Hmtase Setd7Lysine N-Methyltransferase 7Set Domain-Containing Protein 7Set7/9 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusChromosome |
| Alternative ELISA Names | Histone-Lysine N-Methyltransferase Setd7 ELISA kitHistone H3-K4 Methyltransferase Setd7 ELISA kitH3-K4-Hmtase Setd7 ELISA kitLysine N-Methyltransferase 7 ELISA kitSet Domain-Containing Protein 7 ELISA kitSet7/9 ELISA kitSETD7 ELISA kitKIAA1717 ELISA kitKMT7 ELISA kitSET7 ELISA kitSET9 ELISA kit |
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Information sourced from Uniprot.org