Human SETD7 protein (Recombinant) (No-Tag) (STJP019756)

Name: Human SETD7 protein (Recombinant) (No-Tag) (STJP019756)
SKU: STJP019756
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP019756

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Short Description	Recombinant-Human SETD7-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 50mM Tris-HCl buffer (pH 7.5) containing 0.2M NaCl, 5mM DTT, 20%Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)

Gene Symbol	SETD7
Gene ID	80854
Uniprot ID	SETD7_HUMAN
Accession Number	NP_085151
Immunogen	Human
Immunogen Region	1-366aa
Immunogen Sequence	MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGE

Tissue Specificity	Widely expressed. Expressed in pancreatic islets.
Function	Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the KR-STA-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS.
Protein Name	Histone-Lysine N-Methyltransferase Setd7 Histone H3-K4 Methyltransferase Setd7 H3-K4-Hmtase Setd7 Lysine N-Methyltransferase 7 Set Domain-Containing Protein 7 Set7/9
Database Links	Reactome: R-HSA-3214841
Cellular Localisation	Nucleus Chromosome
Alternative Protein Names	Histone-Lysine N-Methyltransferase Setd7 protein Histone H3-K4 Methyltransferase Setd7 protein H3-K4-Hmtase Setd7 protein Lysine N-Methyltransferase 7 protein Set Domain-Containing Protein 7 protein Set7/9 protein SETD7 protein KIAA1717 protein KMT7 protein SET7 protein SET9 protein

Information sourced from Uniprot.org