Human SERPIND1 protein (Recombinant-Active) (C-10*His) (STJP011804)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human SERPIND1-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to inhibit recombinant human Coagulation Factor II/Thrombin cleavage of a fluorogenic peptide substrate BocVPR-AMC. The IC50 value is <1.5 nM, as measured under the described conditions. |
Target Information
| Gene Symbol | SERPIND1 |
| Gene ID | 3053 |
| Uniprot ID | HEP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly20-Ser499 |
Additional Info
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. Isoform 2: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro. |
| Protein Name | Heparin Cofactor 2Heparin Cofactor IiHc-IiProtease Inhibitor Leuserpin-2Hls2Serpin D1 |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | |
| Alternative Protein Names | Heparin Cofactor 2 proteinHeparin Cofactor Ii proteinHc-Ii proteinProtease Inhibitor Leuserpin-2 proteinHls2 proteinSerpin D1 proteinSERPIND1 proteinHCF2 protein |
Information sourced from Uniprot.org