SDS-PAGE gel showing recombinant human Serpin E1 PAI-1 protein 3µg under reducing conditions

Human Serpin E1/PAI-1 protein (Recombinant) (His-Tag) (STJP019715)

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STJP019715
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Short Description :Recombinant-Human Serpin E1/PAI-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Enzyme Activity
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 50mM NaAc (pH 5.5) containing 10% Glycerol, 0.1M NaCl
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Immunoreactivity:The IC50 for this effect is less than 3 nM, Measured by its ability to inhibit uPA cleavage of the substrate Z-GGR-AMC.
Gene Symbol:SERPINE1
Gene ID:5054
Uniprot ID:PAI1_HUMAN
Accession Number:NP_000593
Immunogen:Human
Immunogen Region:24-402aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MVHHPPSYVA HLASDFGVRV FQQVAQASKD RNVVFSPYGV ASVLAMLQLT TGGETQQQIQ AAMGFKIDDK GMAPALRHLY KELMGPWNKD EISTTDAIFV QRDLKLVQGF MPHFFRLFRS TVKQVDFSEV ERARFIINDW VKTHTKGMIS NLLGKGAVDQ LTRLVLVNAL YFNGQWKTPF PDSSTHRRLF HKSDGSTVSV PMMAQTNK
Tissue Specificity Expressed in endothelial cells. Found in plasma, platelets, and hepatoma and fibrosarcoma cells.
Post Translational Modifications Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.
Function Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis.
Protein Name Plasminogen Activator Inhibitor 1
Pai
Pai-1
Endothelial Plasminogen Activator Inhibitor
Serpin E1
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-1368108
Reactome: R-HSA-2173796
Reactome: R-HSA-3000178
Reactome: R-HSA-75205
Reactome: R-HSA-9926550
Cellular Localisation Secreted
Alternative Protein Names Plasminogen Activator Inhibitor 1 protein
Pai protein
Pai-1 protein
Endothelial Plasminogen Activator Inhibitor protein
Serpin E1 protein
SERPINE1 protein
PAI1 protein
PLANH1 protein

Information sourced from Uniprot.org

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