Human SCNN1b (Amiloride Sensitive Sodium Channel Subunit Beta) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018429)
SPECIFICATIONS
General Information
| Short Description | This SCNN1b Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.107ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | SCNN1B |
| Gene ID | 6338 |
| Uniprot ID | SCNNB_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Detected in placenta, lung and kidney. Expressed in kidney (at protein level). |
| Post Translational Modifications | Ubiquitinated. Can be ubiquitinated at multiple sites and undergo monoubiquitination and polyubiquitination. Ubiquitination by NEDD4 or NEDD4L inhibits the ENaC channel through endocytosis, intracellular retention and degradation of its individual subunits. However, some studies could not confirm the ubiquitination of this subunit of the ENaC. Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. N-glycosylated. N-glycosylation is required for interaction with BPIFA1. |
| Function | This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance. |
| Protein Name | Epithelial Sodium Channel Subunit BetaBeta-EnacEnac Subunit BetaEnacbEpithelial Na(+ Channel Subunit BetaAmiloride-Sensitive Sodium Channel Subunit BetaBeta-NachNonvoltage-Gated Sodium Channel 1 Subunit BetaScneb |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-9730628 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle Membrane |
| Alternative ELISA Names | Epithelial Sodium Channel Subunit Beta ELISA kitBeta-Enac ELISA kitEnac Subunit Beta ELISA kitEnacb ELISA kitEpithelial Na(+ Channel Subunit Beta ELISA kitAmiloride-Sensitive Sodium Channel Subunit Beta ELISA kitBeta-Nach ELISA kitNonvoltage-Gated Sodium Channel 1 Subunit Beta ELISA kitScneb ELISA kitSCNN1B ELISA kit |
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Information sourced from Uniprot.org