Human Sclerostin protein (Recombinant) (STJP000679)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding extracellular domain of Human Sclerostin (GLN24-TYR213) including a N-terminal His tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Human Sclerostin-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
Target Information
| Gene Symbol | SOST |
| Gene ID | 50964 |
| Uniprot ID | SOST_HUMAN |
| Immunogen | Optimized DNA sequence encoding extracellular domain of Human Sclerostin (GLN24-TYR213) including a N-terminal His tag was expressed in HEK293 cells. NA |
| Immunogen Region | GLN24-TYR213 |
Additional Info
| Tissue Specificity | Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level). |
| Function | Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. |
| Protein Name | Sclerostin |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Sclerostin proteinSOST proteinUNQ2976 proteinPRO7455 proteinPRO7476 protein |
Information sourced from Uniprot.org