Human Scavenger Receptor Class B Type I protein (Recombinant) (STJP000663)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding I extracellular domain of Human Scavenger Receptor Class B Type I (SR-BI) including a C-terminal His tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Human Scavenger Receptor Class B Type I-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
Target Information
| Gene Symbol | SCARB1 |
| Gene ID | 949 |
| Uniprot ID | SCRB1_HUMAN |
| Immunogen | Optimized DNA sequence encoding I extracellular domain of Human Scavenger Receptor Class B Type I (SR-BI) including a C-terminal His tag was expressed in HEK293 cells. NA |
| Immunogen Region | ECD |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | N-glycosylated. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. |
| Function | Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate. (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus. (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding. |
| Protein Name | Scavenger Receptor Class B Member 1Srb1Cd36 And Limpii Analogous 1Cla-1Cd36 Antigen-Like 1Collagen Type I Receptor - Thrombospondin Receptor-Like 1Sr-BiCd Antigen Cd36 |
| Database Links | Reactome: R-HSA-3000471 Q8WTV0-2Reactome: R-HSA-8964011 Q8WTV0-2 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembraneCaveolaPredominantly Localized To Cholesterol And Sphingomyelin-Enriched Domains Within The Plasma MembraneCalled Caveolae |
| Alternative Protein Names | Scavenger Receptor Class B Member 1 proteinSrb1 proteinCd36 And Limpii Analogous 1 proteinCla-1 proteinCd36 Antigen-Like 1 proteinCollagen Type I Receptor - Thrombospondin Receptor-Like 1 proteinSr-Bi proteinCd Antigen Cd36 proteinSCARB1 proteinCD36L1 proteinCLA1 protein |
Information sourced from Uniprot.org